Vitiligo Comorbidities & Labs: Thyroid, Autoantibodies, Vitamin D, and a Practical Screening Algorithm
Key Takeaways Most actionable comorbidity: autoimmune thyroid disease (subclinical → overt). Start with TSH, reflex to FT4 if abnormal; add […]
autoimmunity
Autoimmunity in Vitiligo: IFN-γ–CXCL9/10 Axis, TRM Cells, and the Relapse Loop
Key Takeaways IFN-γ → CXCL9/10 → CXCR3+ T cells is the central chemokine axis that sustains melanocyte-directed cytotoxicity. TRM cells
Autoimmunity in Vitiligo: IFN-γ–CXCL9/10 Axis and Tissue-Resident Memory T Cells (TRM)
Key Takeaways IFN-γ induces keratinocyte/immune-cell secretion of CXCL9/10, recruiting CXCR3+ cytotoxic T cells that kill melanocytes. CD8+ TRM persist in