Vitiligo Relapse & Maintenance: TRM Biology and Practical Therapy Schemes
Key Takeaways Relapse is driven by tissue-resident memory T cells (TRM) and the IFN-γ–CXCL9/10 chemokine loop that re-recruits cytotoxic T […]
IFN-γ
Autoimmunity in Vitiligo: IFN-γ–CXCL9/10 Axis, TRM Cells, and the Relapse Loop
Key Takeaways IFN-γ → CXCL9/10 → CXCR3+ T cells is the central chemokine axis that sustains melanocyte-directed cytotoxicity. TRM cells
Autoimmunity in Vitiligo: IFN-γ–CXCL9/10 Axis and Tissue-Resident Memory T Cells (TRM)
Key Takeaways IFN-γ induces keratinocyte/immune-cell secretion of CXCL9/10, recruiting CXCR3+ cytotoxic T cells that kill melanocytes. CD8+ TRM persist in
Autoimmunity in Vitiligo: IFN-γ/CXCL9–10 Axis, Tissue-Resident Memory T Cells, and the Koebner Phenomenon
Key Takeaways Vitiligo is driven by cytotoxic, melanocyte-reactive T cells orchestrated by an IFN-γ → CXCL9/10 → CXCR3 chemokine circuit.