Key Takeaways Why relapse? Persistent tissue-resident memory T cells (TRM) linger in previously affected skin and can reignite depigmentation after […]
Key Takeaways Relapse is driven by tissue-resident memory T cells (TRM) and the IFN-γ–CXCL9/10 chemokine loop that re-recruits cytotoxic T
Key Takeaways IFN-γ → CXCL9/10 → CXCR3+ T cells is the central chemokine axis that sustains melanocyte-directed cytotoxicity. TRM cells
Key Takeaways IFN-γ induces keratinocyte/immune-cell secretion of CXCL9/10, recruiting CXCR3+ cytotoxic T cells that kill melanocytes. CD8+ TRM persist in
Key Takeaways Vitiligo is driven by cytotoxic, melanocyte-reactive T cells orchestrated by an IFN-γ → CXCL9/10 → CXCR3 chemokine circuit.
