Key Takeaways Lesional and perilesional skin frequently shows elevated H2O2 and reduced catalase activity, creating a pro-oxidant milieu hostile to […]
Key Takeaways Vitiligo is a complex, polygenic disorder with loci mapping to immune regulation (e.g., HLA, NLRP1, PTPN22, IL2RA) and
Key Takeaways Vitiligo is driven by cytotoxic, melanocyte-reactive T cells orchestrated by an IFN-γ → CXCL9/10 → CXCR3 chemokine circuit.
Key Takeaways Global point prevalence typically falls within ~0.5–2%, with heterogeneity by region and methodology. Childhood onset is common (≈30–50%
Key Takeaways Evidence for vitiligo has progressed from descriptive case series to randomized and phase-3 trials; the most mature clinical
Primary endpoint: Mean % change in F-VASI at week 24 better with NB-UVB vs PUVA (−48.6% vs −39.2%; Δ −9.4
Definition and Prevalence Vitiligo is a chronic skin disorder characterized by the development of depigmented (white) patches on the skin.
